Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL ‘CONH’ BRIDGED INDOLE AND PYRAZINE DERIVATIVES

Ramaling B. Kotnal*

Abstract

A new series of N'-[(E)-phenyl methylidene] pyrazine-2- carbohydrazide and N'-(2-oxo-1,2-dihydro-3H-indol-3-ylidene) pyrazine-2-carbohydrazide derivatives (RBK1–RBK12) were synthesized and evaluated for their antituberculosis, antibacterial and antifungal activities. All the synthesized compounds were in good agreement with spectral analysis. Three synthesized compounds RBK3, RBK4 and RBK9 have shown significant anti-tubercular activity as compared to the reference drug. Compounds RBK7, RBK8 and RBK9 shown good antibacterial activity against gram positive bacteria and compounds RBK6, RBK9, RBK10 and RBK12 shown significant activity against gram negative bacteria. Compounds RBK3, RBK7, RBK10, RBK11 and RBK12 shown significant antifungal activity when compared with standard pyrizinamide, streptomycin, ciprofloxacin, fluconazole were used as the standard drug for the biological activity respectively. The purity and structure confirmation of the synthesized compounds were done by TLC, IR and 1H-NMR spectral study.

Keywords: Indole, Pyrazine, Antibacterial, Antifungal, Anti Tubercular Activity.