Abstract

REVISITING CARDIOPROTECTIVE ROLE OF CURCUMINOIDS: A COMPARISON OF CARDIAC OUTPUT, POSITIVE INOTROPIC, AND NEGATIVE CHRONOTROPIC EFFECTS IN ISOLATED PERFUSED FROG HEART PREPARATION

Vasudeva Rao Avupati*, Nalini Govindasamy, Yuawa Rani, M. Mohamed Shabi, Ashwinder Singh and Prasad Cheepurupalli

Abstract

Curcuminoids, a curcumin (C), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC) were isolated from Curcuma longa L. (C. longa L) by column chromatography and evaluated for relative cardioprotective potential in isolated frog heart preparation. Although DMC and BDMC are also principal curcuminoids but most of the studies reported on the cardioprotective role of C. longa L include C as effective and bioactive curcuminoid, thus DMC and BDMC were less explored. Based on our study, the results suggest that curcuminoids (C, DMC and BDMC) could exhibit cardioprotective activity as evidenced by improved hemodynamic variables such as cardiac output, positive inotropic and negative chronotropic effects. Our results demonstrated that the C has more significant effect on cardiac output, DMC exhibited enhanced negative chronotropic effect (increased heart rate), and BDMC displayed intensified positive ionotropic effect (force of contraction) respectively, which were independently cardioprotective and revealed comparable potency with each other.

Keywords: Curcumin, demethoxycurcumin, bisdemethoxycurcumin, positive inotropic, negative chronotropic, cardiac output, cardioprotection.