Abstract

CHEMICAL COMPOSITION AND ANTICANCER ACTIVITY OF DALDINIA CONCENTRICA (XYLARIACEAE)

Boua Benson Boua*, Minhinle Arsène Christel Oulaguehi, Guy Roger Mida Kabran, Janat Akhanovna Mamyrbekova-Bekro, Marc Lecouvey and Yves-Alain Bekro

Abstract

The mycochemical study of hexanic (EH), ethyl acetate (EE), and ethanolic extracts (EET) of Daldinia concentrica by thin layer chromatography revealed the presence of terpenes, sterols and coumarins. The presence of flavonoids and quinones has been mentioned only in the ethyl acetate and ethanolic extracts. In vitro bioassays performed on the CA 431 cell line, showed the anticancer activity of the extracts with a greater efficiency for the ethanolic extract (IC50 = 0.03 mg / mL), which seems to depend on the coexiting conjugated secondary metabolites detected.

Keywords: Daldinia concentrica, chemical composition, anticancer activity.