Abstract

NOVEL EVALUATION OF IN VIVO ANTI-INFLAMMATORY ACTIVITIES OF PERGULARIA DAEMIA FORSSK

Md. Hasan-Al Jubayed*, Md. Abdur Rahaman Miah, Zannatul Ferdous, Snigda Sarmin Mitheela, Md. Mahmudul Hasan, Mahmuda Siddika Shefa and Rajesh Goswami

Abstract

The pharmacological and chemical constituents of plants from the plant Pergularia daemia Forssk which is widely used in folk medicine. The purpose of this study was to evaluate and compare the antiinflammatory activity of the aqueous stem and leaves extract of Pergularia daemia Forssk. in experimental acute and chronic inflammatory animal models. Methanol extract of Pergularia daemia Forssk was prepared and tested for anti-inflammatory activity in albino rats weighing 150-280 grams. The animals were randomly divided into 3 groups of 6 each; one group served as control and other two groups received indomethacin and Pergularia daemia orally 1 hour prior to experimentation. The in vivo anti-inflammatory activity was studied using the acute (Carrageenan induced paw edema) and chronic (Cotton pellet induced granuloma) animal models. Anti-inflammatory activity was expressed as Percent inhibition (PI). Statistical analysis was performed using One-way analysis of variance (ANOVA) followed by Scheffe's post hoc test. P < 0.05 was considered statistically significant. The PI with indomethacin and Pergularia daemia Forssk in carrageenan induced paw edema were 51.8% and 33.98% and in cotton pellet induced granuloma were 35.53% and 10.9% respectively. Indomethacin showed highly significant anti-inflammatory activity in both the models. However, Pergularia daemia Forssk showed highly significant activity in acute model and but a trend of antiinflammatory activity in chronic model studied. As Pergularia daemia Forssk showed significant anti-inflammatory activity in the models studied, it can be a promising antiinflammatory agent.

Keywords: Pergularia daemia Forssk, anti-inflammatory, carrageenan, granuloma, edema.