Abstract

G6PD DEFICIENCY IN ADULT JAUNDICED SUBJECTS: A CASE STUDY IN HOSPITAL ATTENDING POPULATION OF BHOPAL, INDIA

Manju Tiwari*

Abstract

Glucose 6 Phosphate dehydrogenase is the key enzyme in pentose phosphate shunt (PPS) where it catalyzes the entry step of G6P that forms part of glycolysis. In erythrocytes, this alternate anaerobic pathway for glucose metabolism remains the only source for reduced NADP. Deficiency of enzyme fails to protect RBCs from hemolysis. During the destruction of RBCs is one of the causes of jaundice in humans. The association between G6PD and neonatal jaundice has been reported independently in many countries. The present study investigates the incident of G6PD and correlates it to hematological test and serum Bilirubin test, liver enzymes in adults in hospital attending heterogeneous population of Bhopal. In thhe study patients visiting tree hospitals of Bhopal were analyzed G6PD deficiency by DCIP test for the detection of deficiency and another test like serum bilirubin; liver enzymes were profiled for correlation. The study found a significant difference in the incidence of disease prevalence between male and female. Moreover, G6PD deficiency in patients also showed a low level of hemoglobin and a significant increase in the serum bilirubin. The result of the present study was well in agreement with similar studies throughout the world. The study concludes that G6PD deficiency is predictive of an increased risk for adverse health effects that involve hemolytic anemia resulting in jaundice.

Keywords: Glucose 6 Phosphate Dehydrogenase, Jaundice, Bilirubin, Liver Enzymes, Pentose Phosphate shunt.