Abstract

HEPATO-PROTECTIVE POTENTIAL OF GREEN TEA EXTRACT AGAINST MERCURIC CHLORIDE INDUCED HEPATOTOXICITYIN ADULT WISTAR RATS

S. Usharani*, M. Chitra and R. Anuradha

Abstract

Objectives: This study investigates the Hepatoprotective activity of the green tea extract against mercuric chloride induced toxicity was investigated in rats. Methods: Twenty four adult rats weighing between 180-200 g were used for this study. They were randomly divided four groups (A,B,C & D) whereby group A served as the control while groups B,C and D served as test groups. The parameters studies were liver and kidney marker enzymes and bilirubin in serum. Results: The alterations in lipid profile, lipid peroxidation and antioxidant status in liver & kidney. All these levels are increased in mercuric chloride induced rats in green tea extract treated rats. wistar strain rats were pretreated with mercuric chloride, the levels of enzymes were significantly decreased. these alterations were prevented by green tea extract. Showed the above parameters attained near normal levels and the hepatoprotective activity of green tea extract. Conclusion: The conclusion of this study strongly indicated that Green tea extract has a hepatoprotective action against mercuric chloride induced hepatic damage in experimental animals.

Keywords: Mercuric chloride, Green tea extract, Liver and body weight, Liver and Kidney Marker enzymes, Antioxidant enzymes, Lipid profile Histopathology.