Abstract

K+ATP CHANNELS MODULATE HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL AFTER PRETREATMENT WITH THE K (ATP) OPENER PINACIDIL AND PHOSPHOLIPASE C INHIBITOR ON ETOMIDATE IN THE MICE

Subramaniam Kannan*, Manoj G. Tyagi and Jayaprakash Somasundaram

Abstract

Etomidate intravenous anesthetics that are recognized to have minimaleffects on clinically measured endpoints of cardiovascular function.Thus, they are often used as induction agents in patients withhemodynamic instability. K+ATP channels are known to be activatedby hyperpolarizing agonists, such as diazoxide, pinacidil, cromakalim,K+ATP channel agonists are used as therapeutic agents in a variety ofcardiovascular diseases, including essential hypertension, anginapectoris, myocardial ischemia, and cerebral vascular disease. Thisstudy was conducted to evaluate the effects of the potassium channelopener drug Pinacidil and Phospholipase C inhibitor, U73122 onEtomidate with K+ATP channels opener drug modified the effects on blood pressure, heartrate and hematological parameters like the RBC, WBC, hemoglobin and serum alanine andaspartate amino-transferase enzymes in the mice.

Keywords: ATP-sensitive potassium channel, Etomidate, Phospholipase C inhibitor, hemodynamic.