Abstract

FORMULATION AND EVALUATION OF IMMEDIEATE RELEASE SUBLINGUAL TABLET OF LOSARTAN POTASSIUM USING FACTORIAL DESIGN

Bani Singh Kamal*, Gauniya Anju and Monika

Abstract

Losartan potassium is mainly used to treat high blood pressure, it is a angiotensin II receptor antagonist. it keeps blood vessels from narrowing, which lowers blood pressure and improve blood flow. The basic objective of this study was to produce immediate release sublingual tablet of losartan potassium containing super disintegrants via direct compression, to improve disintegration, dissolution and to get faster onset of action. The drug-excipients interaction was investigated by FT-IR. Various formulation of losartan potassium tablets were prepared and evaluated with respect to the various quality parameters both in process parameters for granules (bulk density, tapped density, compressibility index, Hausner’s ratio, angle of repose and parameters for finished products (average weight, weight variation, friability, hardness, drug content, disintegration time, drug content, in vitro dissolution studies). Tablets were found to be satisfactory when evaluated for all evaluation parameters.

Keywords: Formulation, evaluation, losartan potassium, dissolution studies, FT-IR, friability.