Abstract

POTENTIAL AND COMPARATIVE TESTS OF CEFADROXILE ANTIBIOTICS AS EVALUATION OF THE QUALITY OF ANTIBIOTICS IN CASES OF ANTIBIOTIC RESISTANCE

Danni Ramdhani*, Sri Agung F. K. and Rurynta F. S.

Abstract

Objective: Acute Respiratory Infection (ARI) is an acute infection of any part of the respiratory tract including the paranasal sinuses, middle ear, and pleural cavity. Cefadroxile antibiotics are one of the antibiotics commonly used to treat ARI. The use of antibiotics that are of less quality and can cause treatment is less effective and can cause resistance. This study aims to determine the potential value and comparative test of cefadroxile antibiotics as a quality evaluation. Methods: Test the antibiotic potency with diffusion method to use 3 doses with using antibiotic samples. Comparative test of antibiotic testing by comparing samples with standard against Staphylococcus aureus ATCC 29213 test bacteria. Results: The potential value obtained was 72.92%, and comparative test againts pure strains was 1 : 0.92, and comparative test againts clinical isolates was 1 : 0.99. Conclusion: Potential antibiotic test results indicate that the potential value of the cefadroxile antibiotic used has decreased from the provisions listed in Indonesian pharmacopoeia 95 – 105%, and comparative test were not much different with the standard.

Keywords: Cefadroxile, antibiotic resistence, potential test, comparative test, agar diffusion.