Abstract

PRE AND POST COMPRESSION PARAMETERS OF TABLET AND MANUFACTURING DEFECTS

Govind P. Sukase*, Yuvraj P. Autade, Vinod D. Pawar and Ajinkya R. Kurhe

Abstract

Tablets are defined as solid unit dosage form of medicaments intended for oral use. They became most popular as they were easy in preparation compared to any other type of dosage forms. But the major drawback exists in its manufacturing. Pre and post compression parameters are important since chemical breakdown or interactions between tablet components may alter the physical tablet properties and greatly affect the bioavailability of the tablet system. These are various standards that have been set in the various pharmacopoeias tablets. These include the angle of repose, hausner’s ratio, compressibility index, bulk density, tapped density, void volume, diameter, size, shape, thickness, weight, hardness, disintegration and dissolution character. An industrial pharmacist usually encounters number of problems during manufacturing. Majority of visual defects are due to inadequate fines or inadequate moisture in the granules ready for compression or due to faulty machine setting. Functional defects are due to faulty formulation. In this article we will discuss the imperfections found in tablets along–with their causes and related remedies.

Keywords: Tablet, Pre-compression parameters, Manufacturing defects, Remedies, Dissolution.