Abstract

SOLID LIPID NANOPARTICLES: A REVIEW

Zaynab T. Nasikkar*, Dr. Nilesh M. Khutle and Hanzala T. Nasikkar

Abstract

Solid Lipid Nanoparticles(SLNs) are fast developing field of nanotechnology with many uses in drug delivery because of their nano size and ability to incorporate various drugs. SLNs provides combine advantages of polymeric nanoparticle and lipid emulsion systems to overcome the invivo stability issues that troubles the polymeric nanoparticles and also the conventional drug delivery. SLNs can be used for drug targeting as they incorporate drug into nanocarriers providimg controlled and site specific drug delivery. This paper reviews present state of solid lipid nanoparticles discussing about its aims, production procedures, need, advantages, limitations and possible remedies available. Also a discussion of analytical techniques used for the characterization of SLN is given like differential scanning calorimetry(DSC), scanning electron microscopy(SEM), photon correlation spectroscopy (PCS), etc.

Keywords: Solid lipid nanoparticles, Colloidal drug carrier, Nanotechnology, homogenization.