Abstract

ANTI-TUMOR ACTIVITY AND ANTI-OXIDANT STATUS OF EUPHORBIA THYMIFOLIA LINN AGAINST EHRLICH ASCITES CARCINOMA IN SWISS ALBINO MICE

G.C. Mamatha*, T. Prabhakar, Pandya Naitik, V. Madhuri, K. Neelima & V.N. Raju Erumalla

Abstract

Aim: To study Anti-tumor effect and anti-oxidant status of Euphorbia thymifolia Linn Materials & Methods: The present study deals with life span of Ehrlich ascites carcinoma bearing hosts, peritoneal cell count, hematological profile, solid tumor mass and biochemical parameters such as lipid peroxidation, reduced glutathione, superoxide distmutase and catalase activities. Results: Euphorbia thymifolia at oral dose of 200mg/kg prolongs the life span of Ehrlich ascites carcinoma-tumor bearing mice and causes significant increase in number of peritoneal cell count and significant decrease in volume of solid tumor mass compared to Ehrlich ascites carcinoma bearing control animals. Hematological profile including Red blood cells count, White blood cells count, Hemoglobin and protein estimation were found to be nearly normal levels in extract treated mice compared to tumor bearing control mice. Euphorbia thymifolia significantly decreased the levels of lipid peroxidation, reduced glutathione and significantly increased the levels of superoxide distmutase and catalase in treated group of animals. Conclusion: The results of the present study suggest that ethanolic extract of Euphorbia thymifolia is an effective anti oxidant and anti tumor activity against Ehrlich ascites carcinoma tumor in mice.

Keywords: Anti-oxidants, Ehrlich ascites carcinoma, Euphorbia thymifolia