Abstract

ANALGESIC ACTIVITY OF NARKARANTHAI LEGIUM- PRE CLINICAL STUDY IN SWISS ALBINO RATS

Dr. A. Janakiram*, Dr. A. F. Glara and Prof. Dr. S. Kaniraja

Abstract

Siddha system is an ancient system of Tamilnadu. It has practiced from 5000 years ago. Psoriasis named as kalanjagapadai quoted in siddha textbook. It is a long lasting auto immune disease characterized by patches of abnormal skin. These skin patches are typically red, dry, itchy, and silver coloured scales. Psoriasis varies in severity from small, localized, patches to complete body coverage. In severe cases, the plaques will grow and merge into one another, covering large areas. Symptoms of psoriasis are itchy, painful skin that can crack or bleed. Small areas of bleeding where the involved skin is scratched. Pain is one of the symptoms of psoriasis. Prevalence of psoriasis in India ranges from 0.44 to 2.8%. Narkaranthai Legium is a poly herbo-mineral siddha medicine. This medicine is quoted in siddha book Bramamuni karukkadai choothiram 380 for the treatment of psoriasis. In this pre-clinical study, the author has aimed to evaluate the analgesic activity of Narkaranthai legium compared with the standard drug pentazocine in Swiss albino rats by Eddy’s hot plate method. The results suggest that Narkaranthai legium (NKL) have an analgesic activity.

Keywords: Siddha medicine, Narkaranthai legium, Analgesic activity, Swiss albino rats, Pre- clinical study, Psoriasis.