Abstract

PRECLINICAL EVALUATION OF SAGALA VAAIVU KUTTHALUKU KIYAZHAM-TOXICOLOGICAL AND PHARMACOLOGICAL STUDY ANTIOXIDANT AND ANTI CANCER ACTIVITY

Shasikala B. V.* and Mohamed Musthafa M.

Abstract

Siddha system of medicine is compiled by siddhars who embodiment of divine knowledge. Nowadays documented medical system which deals with physical, psychological, spiritual wellbeing of individual. Here the drug Sagala Vaaivu Kutthaluku Kiyazham taken from Siddha text. The primary purpose of this preclinical study is to evaluate the efficacy and safety of the drug which will help the medicine for widespread global acceptance. A study was performed as per OECD guidline-423 and no other significant changes were observed in animal models. The anticancer activity study was conducted in HT29 cell line and proven to be potent anticancer activity drug. The antioxidant study was determined by DPPH assay and hence proven to be a potent radical scavenging drug. The overall study results that Sagala Vaaivu Kutthaluku Kiyazham (SVKK) has high efficacy and safety in preclinical assessment and expect to give best result on management of colorectal cancer in future study.

Keywords: Sagala Vaaivu Kutthaluku Kiyazham (SVKK), Anticancer activity, Antioxidant activity, HT29 Cell line.