Abstract

EVALUATION OF IN VITRO ANTIASTHMATIC ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF AILANTHUS EXCELSA (ROXB.)

Raj Tilak* and Amita Tilak

Abstract

The main objective of the work was to evaluate the use of Ailanthus excelsa (Roxb.) (AE) leaves for safety and efficacy in the treatment of asthma. The anti-asthmatic activity of the extract by using methanolic extract was evaluated in isolated goat tracheal chain preparations by using histamine. The similar concentration-effect curve was taken in presence of standard drug Chlorpheniramine Maleate (1 μg/ml). In the present study, histamine produced dose dependent contraction of goat tracheal chain preparation, as number of papers with antiasthmatic activity are reported with use of guinea pig ileum, tracheal chain preparation but yet antiasthmatic activity was not carried out using tracheal chain hence present study was designed using goat tracheal chain preparation. The modified physiological salt solution containing methanolic extract of Ailanthus excelsa significantly inhibited the contractile effect of histamine thus produces significant bronchodilation. It is concluded that Ailanthus Excelsa showed potent antiasthmatic activity due to bronchodilator activity.

Keywords: Antiasthmatic, Ailanthus excelsa (Roxb), Histamine, Goat Tracheal Chain.