Abstract

A COMPARISON OF PVP, PEG6000, PVA AS PENETRATION ENHANCES FOR PARACETAMOL TRANSDERMAL DRUG DELIVERY SYSTEM

P. Mounika*

Abstract

Paracetamol is analgesic & antipyretic agent, mostly used for children & infants. The main aim of this research is the children who are unable to take medicine in different dosage forms like tablets, capsules & syrups etc, TDDS is a suitable route for administration of drug. The half-life of a drug is 1-4 hours which makes it suitable for TDDS. Transdermal patches are prepared by solvent casting method using starch as a polymer. The main object of this study is to compare the individual effect of penetration enhancers on Paracetamol TDDS. Prepared patches are evaluated for thickness, Folding endurance, drug content, Invitro penetration study was performed by using Franz diffusion cell.

Keywords: Paracetamol, Starch, PVP, PEG6000, PVA, Solvent casting method.