Abstract

TREATMENT STRATEGY AND BIO ANALYTICAL METHODS FOR ESTIMATION OF ANTI-VIRAL DRUGS IN THEIR BIOLOGICAL SAMPLES –A REVIEW

Faiza Habeeb*, Imam Pasha S. and Anupama Koneru

Abstract

This paper describes treatment strategy for viral infections and the various anti-viral drug estimation methods reported for quantitative estimation in the biological samples of in vivo systems. These methods are said to be used for IVIVC studies and for toxicity studies. The various extraction procedures adopted for avoiding the matrix effect in various methods were described. Quantification of active drug moiety in the presence of the metabolites and other biological products is typical task for the analyst, but in spite of costly extraction procedures, it’s mandatory for therapeutic drug monitoring in order to assess the toxicity and to adjust the dose and it’s frequency to maintain the therapeutic window and subsequently in the pharmacokinetic profiling.

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