Abstract

AN INSIGHT TO THE BIOMARKERS AND POTENTIAL NEW DIAGNOSTIC TOOL FOR DIABETIC NEUROPATHY

Prajakta V. Bhoir*, Ghanshyam B. Jadhav and Arpit K. Maurya

Abstract

Diabetes is an increasing epidemic worldwide and associated diabetic neuropathy is its most common disabling complication. Despite the global prevalence and severe complication of diabetic mellitus, the pathophysiological mechanism of diabetic neuropathy has not been elucidated. As diabetic neuropathy has different clinical manifestations it is very difficult to get early detected. Early diagnosis is recommended and is a key factor for the effective prognosis and prevention of further complications. However, diagnostic tests for diabetic neuropathy are not accurately established due to numerous pathologies developing from the nerve injuries and different mechanisms due to diabetes. So, biomarker is the key area for the research which can extensively useful for early detection of disease, monitoring of its severity and progression as well as to design accurate treatment regimen. We have reviewed available biomarkers which are used in diabetic neuropathy studies along with some potential new biomarkers which can be useful for the early detection of diabetic neuropathy.

Keywords: Diabetes, Neuropathy, Biomarkers, diagnostic tools.