Abstract

A REVIEW: PROLIPOSOMES AS A STABLE NOVEL DRUG DELIVERY

Shivani Patel*, Dr. Rakesh Patel and Dr. Abhay Dharamsi

Abstract

Liposome, the microscopic phospholipids vesicles, and a novel drug delivery system that allow drug at the pre-established rate decided according to requirements, pharmacological aspects, drug profile, physiological conditions of body etc. But the liposome betrays low stability problem and due to this storage problem arise. To overwhelm this problem, Proliposomes (PLs) were discovered in 1986. Proliposomes are free-flowing granular products that consist of drug and phospholipids precursors which on hydration converted to the liposome. This paper reviews various features regarding pro-liposome, their method of preparation, evaluation, applications and focus its potential to be chosen for different routes of administration.

Keywords: Liposome; Pro-liposome; Carriers; Phospholipids; Cholesterol.