Abstract

FORMULATION AND EVALUATION OF BILAYERED TABLETS OF LOVASTATIN AS IMMEDIATE RELEASE AND ATENOLOL AS CONTROLLED RELEASED TABLET

P. Mounika*, Abhishek Pandey, Kishore M. R. and Sanjit

Abstract

In this present study bilayered tablet of Lovastatin and Atenolol were designed. lovastatin is a antihyperlipoprotienemic agent which acts as a cholesterol -lowering agent, Due to its short duration of action makes the drug suitable for immediate release, and it has poor solubility in water. lovastatin was incorporated as immediate layer and atenolol as controlled release layer. Bilayered tablet contains two layers. We can formulate first layer into immediate release and second layer into sustained release for desired action. Lovastatin have half-life 2-4hrs make the drug suitable for immediate release. Atenolol have half-life 6-7hrs make the drug suitable for sustained release. Lovastatin has poor solubility in water, Solid dispersions method is used to enhance the solubility of lovastatin. In this formulation using super disintegrants for immediate release, HPMC and ethyl cellulose as a polymers for Controlled release. In this study Bilayered tablets of lovastatin and Atenolol tablets were evaluated for weight variation, hardness, thickness, drug content and In-vitro studies.

Keywords: Lovastatin, Atenolol, HPMC, Ethylcellulose, PEG6000, Avicel PH102, PVA, Lactose.