Abstract

DEVELOPMENT OF LIPOSOMAL FORMULATION: FROM FORMULATION TO STERILIZATION

Shreya Mahesh Suthar* and Bhargavi Ankit Rathva

Abstract

Liposomes are spherical vesicles containing of more than one phospholipid bilayers. Liposomes are one of most efficient drug delivery systems which reduce toxicities of traditional drug and increases healing effect hence helps in reducing the dosing frequency. Today, liposomes are a very efficient and used as carrier for various drug, bacteria, virus and vaccines in various scientific disciplines amongst several different drug delivery systems, at present various liposomes formulation are in use of medical research because of their fast healing characteristic. Liposomes with changed surfaces have also been produced utilizing various atoms, alongside glycolipids or sialic acid. There are numerous liposomal formulations, which include EndoTAG1 (paclitaxelstacked cationic liposomes), Lipoplatin (cisplatin-stacked long circling liposomes) and Stimuvax (a malignancy antibody), showing promising mending cost in logical studies. Presently, filtration and aseptic production are encouraged for the coaching of sterile liposomal merchandise. Numerous liposome primarily based drug components are authorised for medical use and many are beneath sizeable investigation. Thus, this noticeably simple technique has particular benefits for encapsulating treasured water-soluble materials. The preparation, advantages and limitations with respect to industrial application and regulatory requirement of the liposomes are defined in detail in this paper.

Keywords: Liposomes, Drug delivery system, Sterilization, Glycolipids, Drug Targeting.