Abstract

INHIBITION OF HUMAN GLIOBLASTOMAS BRAIN CANCER CELL LINES BY METAL-CONTAINING POLYMERS

Charles E. Carraher Jr.*, Michael R. Roner, Jessica Frank, Francesca Mosca, Paul Slawek and Lindsey Miller

Abstract

We have been investigating the inhibition of a variety of human cancers including pancreatic, prostrate, breast, lung, ovary and colon employing metal-containing polymers. Recently we found that we could inhibit human glioblastomas brain cancer cells using these same polymers as well as specially designed polymers containing Lewis bases that themselves cross the brain blood barrier. Here we describe some of these results. These efforts are a precursor to studying brain cancer in live animals and eventually humans. A comparison between the various reactants and their ability to inhibit the human brain cancer cell lines is described.

Keywords: Cancer, inhibition brain cancer, organotin polymers, metallocene polymers, human glioblastoma brain cancer.