Abstract

EVALUATION OF THE COMBINATION OF TWO HERBAL DRUGS IN MIDDLE CEREBRAL ARTERY OCCLUSION INDUCED BRAIN STROKE IN RATS

Meenu*, Hina Chadha, Smriti Ojha and Sokindra Kumar

Abstract

Stroke is defined as brain injury which is caused by a sudden obstruction in the blood circulation to the brain. When blood supply altered/arrested about two million brain cells die in each second, which can increase the risk of brain damage, disability and death. Present study focused on the fact that the combination of the hydro alcoholic extract of Eclipta alba and Centella asiatica can reverse MCAO induced brain stroke, protect brain form stroke and protect brain from other complication which are precipitated by brain stroke. In MCAO treated group MDA level was increased significantly and GSH was significantly decreased compare to control and SHAM group. These altered biochemical parameters were restored to normal values significantly respectively by administering hydro alcoholic extract of combination of Eclipta alba and Centella asiatica extract and melatonin. The results of present study suggest that the combination of eclipta alba and centella asiatica is more potent than individual drug treatment, and contains oxidative stress reducing properties, neuroprotective property and prevent brain stroke as well as minimize the symptoms of stroke.

Keywords: Stroke, brain, oxidative stress, neuroprotective, ischemia.