Abstract

GENE AND DISEASE: AN ‘‘OMICS’’ AS THE PILLARS OF SYSTEMS MEDICINE

Aaishwarya Deshmukh*

Abstract

In the age of systems medicine, the pathological set of connections, genetic mutations, allied anomalous pathways, and a response of drug for rectification of the abnormalities/disease are integrated transversely with the human biology systems by employing varied approaches of genomics, epigenomics, transcriptomics, and proteomics technologies. Pharmacogenomics studies the variation in human genome which is employed to predict responses to a specific drug or class of drugs. In recent years with the growth of pharmacogenomics, the concept of personalized medicine has becomes more often accessible in clinic settings for patient care. Most importantly, the rational case for genetics-specific drug selection and dosing is considered more established than the handy list of drugs for which outcomes are demonstrably improved. Thus significant accomplishment is possible with an interdisciplinary approach of genetics, technological and therapeutic measures establishing “OMICS” technologies as the pillars of systems medicine.

Keywords: OMICS, Gene, Disease, Genetic variability, Drug response, Pharmacogenetic.