Abstract

REVIEW ON SYNTHESIS AND SPECTRAL ANALYSIS OF 1, 3, 4- OXA/THIADIAZOLE MOIETY BASED ON THEIR LITERATURE SUPPORT

Harshdeep Garewal* and Jeevan Patra

Abstract

A new derivatives of 1, 3, 4-oxa/thiadiazole 4a-4g was synthesized by diazotization of these corresponding amines of diazoles and coupled with 8-hydroxy quinoline and 2-napthol in mild condition. Diazotisation of these compounds were carried out in presence of sodium nitrite and concentrated HCl to give hetero aryldiazonium salts which immediately coupled with two different coupling agents in ice cold solution of alkalis. Thiadiazole and their derivative are prepared by the mixture of formic acid and thiosemicarbazide in ammonia solution whereas oxadiazole was also prepared by the mixture semicarbazide and formic acid in same condition. All the synthesized compounds were characterized by elementary analysis, FT/IR, 1H NMR of their confirmation structure. The purity of these compounds was checked by TLC and recrystalised by ethanol solvent. These prepared compounds shows azo functionality and oxa/thiadiazole motif with connecting coupled component in same structural frame.

Keywords: Diazo-coupling reaction, oxa/thiadiazole, spectral characterization.