Abstract

SYNTHESIS AND INVIVO ANTICONVULSANT EVALVATION OF 1- {5-[4-(MORPHOLIN-4-YL) PHENYL]-1,3,4-OXADIAZOL-3(2H)-YL} ETHANONE DRRIVATIVES

Somashekhar M.* and R.B. Kotnal

Abstract

The chemistry of heterocyclic compounds has been an interesting field of study for a long time. Various heterocyclic compounds along their derivatives were evaluated for their biological activities. The widespread use of 1,3, 4 –oxadiazole as a scaffold in medicinal chemistry establishes this moiety as an important bioactive class of heterocyclic compounds. These compounds have biological properties like antipyretic, antimitotic, antitubercular, antimicrobial, antiviral, antitumor, anticonvulsant, antibacterial, antifungal, antituberculosis, analgesic, anti-inflammatory, antidiabetic, antihistamine and other biological activities. The parent tetrahydro-1,4-oxazine, commonly called morpholine, is produced on a large scale for use as a solvent, corrosion inhibitor, and fungicide. The morpholine ring is also present in the sedative-hypnotic drug trimetozine and in some fungicides such as tridemorph and fenpropimorph. The novel derivatives of 1-{5-[4-(morpholin-4-yl) phenyl]-1,3,4-oxadiazol- 3(2H)-yl} ethanone has been biologically screened for in-vivo and in-vitro anticonvulsant activity and reported. This research work can be helpful to develop various more new compounds possessing 1,3,4-oxadiazoles and Morpholine moiety that could be better in terms of efficacy and lesser toxicity.

Keywords: 1,3,4-Oxadiazole, Morpholine and Anticonvulsant.