Abstract

ZIDOVUDINE: FORMULATION AND DEVELOPMENT OF MATRIX TABLETS

Pawankumar Rai*

Abstract

The aim of the preset study was to formulate and evaluate controlled release matrix tablets of Zidovudine which was used as a model drug and by incorporating the drug in matrix forming hydrophilic polymers such as HPMC in different ratios, hydrophobic polymer such as Carbopol were used as release modulators. Primary objective of this study is to improve bioavailability, to prevent fluctuation of concentration of the drug in plasma, to reduce dosing frequency thereby to improve patience compliance through oral controlled release matrix systems. Study of pre-compressive parameters and postcompressive parameters for the prepared matrix tablets like; Hardness test, Weight variation test, uniformity of size and drug content, study of swelling behavior, In-vitro dissolution studies. The data will be subjected to statistical analysis mechanism and kinetics of release shall be studied and reported. Accelerated stability studies for the final formulations according ICH guidelines. Drug-excipients compatibility study by FTIR Spectroscopy.

Keywords: Zidovudine, HPMC, Matrix, Hydrophilic gels.