Abstract

ONE POT SYNTHESIS OF PIPERIDONE BASED TRANSITION METAL COMPLEXES AND THEIR ANTIOXIDANT AND ANTIFUNGAL ACTIVITY STUDIES

G. Balakrishnaiah, Javarappa Rangaswamy and Nagaraja Naik*

Abstract

Transition metal complexes containing tri-dentate ONO donor ligand i.e., 2,6-bis(2-hydroxyphenyl)piperidin-4-one (BHP) (2) have been achieved by one pot multicomponent reaction with salicyaldehyde and acetone in presence of ammonium acetate. The ligand forms complexes (M1-M7) with different salts of Co(II), Cu(II), Ru(III) in good yield. The newly synthesized ligand and their respective complexes were characterized by elemental analysis, molar conductance measurement and various spectral studies such as infrared (IR), electronic, and NMR (for ligand only)]. The proposed geometries of the complexes are octahedral in nature. The antioxidant and antifungal activity of the synthesized complexes was studied against DPPH radical and different microbial strains. The study showed that all synthesized ligand and their complexes were exhibits certain degree of antioxidant and antimicrobial activities. Among them Ru(M7) and Co(M3) complexes exhibits effective antioxidant and Cu(M4) and Co(M2) complex showed highest antifungal activity.

Keywords: Piperidone ligand, Metal complexes, Antioxidant, Antifungal.