Abstract

DEVELOPMENT AND EVALUATION OF FLUOCINOLONE ACETONIDE AND NEOMYCIN SULPHATE NANOMIEMGEL FOR TOPICAL DRUG DELIVERY SYSTEM

Salman J. Latif* and Dr. Shubhangi C. Daswadkar

Abstract

Objective: The skin enacts as the effective barrier which prevents permeation of numerous drug through it. Nanomiemgel is a combination of two novel drug delivery systems i.e. nano-micelles and nano-emulsions. This combination provides synergistic approach providing the benefit of prolonging the duration of action, increased incidence on skin thereby increasing the contact time, maintaining steady state concentration, improving solubility of poorly soluble drugs and decreasing the toxicity. Method: Firstly the nano-emulsion is formed by sonication method with the aid of surfactant mixture of tween 80 and oleic acid. Further the nano-micelles are formed by solvent evaporation method. The gel was formed by using carbopol and triethanolamine in which both the nano-emulsion and nano -micelles are incorporated. Results: The nano-emulsion, nano-micelles and nanomiemgel were evaluated for physical appearance, pH and viscosity was found to be within critical limits. The in-vitro release for the nanomiemgel was found to be 98.7%. The globule size for nano-emulsion and nanomicelle were 92.95nm and 70.79nm respectively. Conclusion: by formulating the nanomiemgel the incidence of the drug on the skin increases as well as the controlled release of the drug is achieved. The stability of the both the preparations is increased and toxicity is also decreased.

Keywords: Nano-emulsion, nano-micelles, nanomiemgel, fluocinolone acetonide, neomycin sulphate.