Abstract

PREPARATION AND EVALUATION OF KETOCONAZOLE NIOSOMAL GEL DRUG DELIVERY SYSTEM BY ULTRASONICATION METHOD

Mukesh Mohite* and Tanvi Kumbhar

Abstract

Objective: Niosomal drug delivery system is an effective as well as the advanced path marching towards novel drug delivery system. Ketoconazole is known as an azole antifungal that acts by inhibiting the growth of fungus. The main objective of the study is to achieve control release and prolong the action of ketoconazole by formulating as niosomes. Method: In this study the niosomes are formulated by using sonication technique and it is further converted to a gel drug delivery system so as to obtain control release. The results of this study showed that CHO content and the type of surfactant increased drug release rate from niosomes. Formulation consisting the surfactant and CHO ratio 1:0.2 showed higher drug release. Results: The λmax of drug was found to be 246 nm and the Beer Lambert’s range was found to be 10-50 ug/ml, the globule size of the niosomes by optimum batch was found to be 65.50nm, the viscosity of the niosomes was found to be 450 cps. pH of the optimum formulation was found to be 6. The in-vitro release showed 98.22%drug release in 5 hours. Conclusion: From all these studies which were carried out, it was concluded that a gel formulation containing niosomes loaded with Ketoconazole provides control release and long duration of action than containing Ketoconazole in nonniosomal form and it can be developed successfully to improve the antifungal activity.

Keywords: Niosomes, Antifungal Agent, Surfactant, sonication.