Abstract

ASSESSMENT OF SEDATIVE ACTIVITY OF SYZYGIUM CUMINI LEAVES ON ANIMAL MODELS – AN IV-VIVO DESIGN

Akshay Kumar Kompelly, Swathi Kompelly, Shirisha Manchikatla,
Vamshi Koyagura, Swetha Naram Reddy* and Vasudha Bakshi

Abstract

In a biological system, a sedative is defined as any substance that that induces calmness or sleep is called sedative. Recently, increasing attention has been focused on the use of natural sedatives. The aim of present study is to evaluate the sedative activity of Syzygium cumini leaf extracts on animal experimental models using rota rod apparatus and Hole cross test. In the recent years, the use of herbal products has been increasing in developing countries. Syzygium cumini is one of the widely used medicinal plants in the treatment of various diseases in particular diabetes. The present review has been primed to describe the sedative effect of Syzygium cumini leaf extracts, traditional uses, chemical constituents and pharmacological actions. The evaluation of the sedative activity was performed in the Rota rod apparatus and Hole cross test. The leaves are claimed to contain glycosides, flavonoids, phenolic acids, triterpenoids, myricetin, quercetin, tannins etc. The vast number of literatures found in the database revealed that the extracts of different parts of Jambolan showed significant pharmacological actions. We suggest that there is a need for further investigation to on the sedative effect of Jambolan leaf extracts, which confer the pharmacological action. Hence evaluation of sedative activity is useful for producing drugs in the treatment of various diseases.

Keywords: Syzygium cumini, sedation, Swiss Albino mice, Rota rod apparatus, Hole board test.