Abstract

APPLICATIONS OF NASAL NSAIDS IN ALZHEIMER’S DISEASE

D. P. Kawade* and M. Y. Hedaoo

Abstract

Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. Epidemiological observation indicates that long-term oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen to patients having rheumatoid arthritis results in reduced risk and delayed onset of Alzheimer's disease. Alzheimer’s disease starts in the entorhinal cortex, which is closely connected to the olfactory nerves, and spreads anatomically in a defined pattern. Therefore, a nasal NSAID would readily reach the region of the brain where it is most likely to be therapeutic. This study provides a general overview on the role of neuroinflammation in these neurodegenerative diseases and an update on NSAID treatment in recent experimental animal models, epidemiological analyses and clinical trials.

Keywords: Non-steroidal anti-inflammatory drugs, Alzheimer's disease, Parkinson's disease, cyclooxygenase, neuroinflammation, Prostaglandins etc.