Abstract

EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SIVATHAI CHOORANAM IN WISTER RATS

Dr. A. Janakiram*

Abstract

Aim: To study the Anti-inflammatory effect of Sivathai Chooranam (SC) in the Male Wister rats of Carrageenan- induced localized inflammation. Method: The paw oedema volumes of the test compounds, standard and control groups were measured at 0, 1, 2, 3, 4, 5, 6th hr after Carrageenan treatment with the help of Digital Plethysmometer. Mean increase in paw oedema volume after Carrageenan injection was measured and the percentage of inhibition was calculated. Drug and solutions 1. Carrageenan (0.1ml of 1%) 2. Diclofenac sodium (10mg/kg IP) 3. Sivathai Chooranam 1gm BD. Results: The results showed significant (p<0.05) anti inflammatory activity when compared to control group. Conclusion: The test drug SC shows potent Anti-inflammatory activity at the concentration of 3.024mg/kg compared to standard drug, Diclofenac Sodium.

Keywords: Siddha medicine, Sivathai Chooranam, Anti-inflammatory activity, Carrageenan induced localized inflammatory pain, Male Wister rats.