Abstract

COMBINATORIAL CHEMISTRY: A NEW APPROACH OF DRUG DISCOVERY

Urmila K. Dholi* and Mr. Ravindra B. Gavali

Abstract

Combinatorial chemistry is providing significant impetus to new innovations in synthetic chemistry. Combinatorial chemistry has rapidly become the rising star among research methods, allowing scientists to efficiently test the feasibility of a multitude of new compounds. The pursuit of new drugs is but one challenging field in which these combinatorial methods are particularly advantageous, helping researchers meet the modern-day demands of a highly competitive environment. This article emphasises that modern combinatorial synthesis is possible not only in the solid phase, but also in solutions. Moreover, it discusses computer-assisted methods as well as the apparatus and instrumentation required for the combinatorial method. Combinatorial chemistry is to be able to synthesize, purify, chemically analyze & biologically testing all structures in library, here it describes the use in drug design & discovery to find new lead structures in shorter time.

Keywords: Combinatorial chemistry, Drug discovery, Combinatorial library, Resins, Combinatorial synthesis.