Abstract

EVALUATION OF ANTI-DEPRESSION EFFECT OF KRISHNA MUSHALI (CURCULIGO ORCHIOIDES) IN MICE

Sudipa Saha*, Partha Biswas and Ashok Bishnoi

Abstract

Back Ground: The depressive illness is one of the most common psychiatric disorder. Major depression represents a significant public health problem globally. The high prevalence of suicide among depressed patients (15%) coupled with complication arising from mental stress condition and its effects on the cardio-vascular system have suggested that it will be second leading cause of death by 2020. Objective: Present study was undertaken to evaluate the anti depressant activity of Curculigo orchiodes. (Krishna Musali.) in mice. Materials and Methods: The immobility time of control and treated mice were recorded in Tail suspension (TST) and Forced swim test (FST) models. The control group (10 ml of distilled water /kg, p.o), Fluoxetine (20 mg /kg bwt.p.o), extract of C.orchioides (200 mg and 300mg /kg. bwt, p.o respectively) were administered once a day for 10 days 1 hour prior to experiment. Results: It was observed that extract of c. orchioides produced significant antidepressant effect at a dose of 200mg and 300mg /kg as compared to control group as indicated by reduction in immobility time of mice in both FST and TST. Conclusion: It can be concluded from the present study that extract of c.orchioides has a significant antidepressant activity in animal models.

Keywords: Antidepressant activity, Forced swim test, Tail suspension test.