WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

PHYTOCHEMICAL SCREENING AND STUDIES ON THE EFFECTS OF ORAL ADMINISTRATION OF PALM WINE EXTRACT OF DATURA STRAMONIUM ON THE ACTIVITY OF TISSUE ENZYMES AND HISTOPATHOLOGY OF ALBINO RATS.

Sanni, M., Ejembi, D. O., Abbah, O. C., Olajide, J.E, Ayeni, G., Usman, S.S., and Salifu, M.

Abstract

Phytochemical screening and the effects of oral administration of palmwine extract of Datura stramonium on the activity of tissue enzymesand histopathology of rats was investigated. Forty (40) experimentalrats of average weight of 100-150g were divided into four groups; A,B, C, and D comprises ten (10) rats each. Subgroups A, B, and C wereadministered with varying concentrations of palm wine extract ofDatura stramonium, and group D served as the control group. Theanimals were kept in separate metabolic cages and fed with rat chowwith water provided ad libitum. Rats in each group (A, B, C) wheregiven 0.5ml/ kg body weight of the extract per day and sacrificed afterday 7, 14, and 21. Rats in the control group (D) were given 0.5ml/ kg body weight of freshpalm wine daily. The enzyme activities acid phosphatase (ACP), aspartate amino transferase(AST) and alanine amino transferase (ALT) were measured. The serum total protein wasmeasured using Biuret method. Histological analysis was carried out on the tissues (kidney,liver and intestine). A significant increase (p<0.05) in the activity of the enzyme (ACP, ALTand AST) and a significant decrease (p<0.05) in total serum protein were observed. Tissuebiopsy showed a clear evidence of cell erosion in the treated groups, which was not apparentin the control group.

Keywords: Datura stramonium, ACP, AST, ALT.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More