Abstract

A COMPREHENCIVE REVIEW ON FLOATING PULSATILE DRUG DELIVERY SYSTEM

Mayuresh R. Redkar*, Dr. Sachinkumar V. Patil, Sonal Y. Nalkar, Ashwini Pandav, Amit A. Shahapurkar

Abstract

Conventional controlled release drug delivery systems are based on single-or multiple-unit reservoir or matrix systems, which are designed to provide constant or nearly constant drug levels over an extended period of time. Pulsatile drug delivery is one such system there by delivering drug at the right time, right place and in right amounts and holds good promises and provides benefit to the patients suffering from chronic problems like arthritis, asthma, hypertension etc. A single dosage forms provided an initial dose of drug followed by one release free interval after which second dose of drug is released, which is followed by additional release free interval and pulses of drug release. The ability to deliver a bioactive compound and therapeutic agent to a patient in pulsatile release profile is major goal in the drug delivery.

Keywords: Chronotherapy, Floating pulsatile release tablet, Controlled release drug delivery.