Abstract

FORMULATION ASPECTS BY APPROACHING DIFFERENT POLYMERS OVER MATRIX TABLETS

Kailas Tarkase*, Sandesh Bole*, Snehal Khatke, Sonal Shinde and Sagar Yenare

Abstract

An ideal drug delivery system should aid in the optimization I the drug therapy by delivering an appropriate amount to the intended site at a desired rate. An oral drug delivery system providing a uniform drug delivery can only partly satisfy therapeutic and biopharmaceutical needs, as it doesn’t take in to account the site specific absorption rates within the Gastrointestinal Tract (GIT). Therefore there is a need of developing drug delivery system that release the drug at the right time, at a specific site and desired rate. A matrix system consists of active and inactive ingredients that are homogeneously dispersed and mixed together into dosage form. In this, we discuss about oral controlled release dosage form and its various polymers used to formulate in sustained release matrix tablet. The use of polymer in the matrix tablet is to controlling the drug release and play important role in formulation.

Keywords: Polymer, Matrices, Drug Release, Dissolution, Diffusion, Biological factors, Physiological factor etc.