Abstract

OPTIMIZATION OF BI LAYERED FLOATING TABLET OF SUCRALFATE AND METOPROLOL SUCCINATE

Sreedhar Ranjan Das*, Dr. Bibhuti Bhusan Panigrahi and Dr. Manoj Kumar Pani

Abstract

Objective: To optimize Bi layered floating tablet (SFMS) containing ulcer protective Sucralfate as immediate release layer and anti hypertensive Metoprolol Succinate as sustained release layer. Method: 15 formulations of Sucralfate and 10 formulations of Metoprolol Succinate is taken. By changing the concentration of Superdisintigrant, Surfectants, Alkalizing agents & Binding agents of Sucralfate and changing concentrations of Alkalizing agents and Polymers of Metoprolol Succinate the OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) is generated. Result: Within 5 minutes in acidic medium, 7% Superdisintigant (Crosspovidone), 7% Surfectant (Polysorbate-80), 15% Alkalizing agents(Sodium bicarbonate), 5% HPC (Binding agent) averagely produce 68.56% drug release. Within 20 hours in acidic medium, 30% Alkalizing agents(Sodium bicarbonate), 50% Soluablepolymer (HPMC K), 40% Polymer (Udragid RSPO, 35% HPC Polymer(NaCMC), 30% Polymer (Sodiumalginate), 25% Polymer (HPC), 20% Polymer, Udragid RS), 5% HPC Polymer (PVPK) produce averagely 100.06% drug release. Conclusion: The optimized formulation 400 mg tablet weight of OSFMS (Optimized Sucralfate and Metoprolol Succinate Formulation) produce better result and identified as better formulation for further studies.

Keywords: Optimization. Sucralfate, Metoprolol Succinate, Bi-layered Floating Tablet.