Abstract

HYDRAZONE LINKAGE BASED SCHIFF BASE: SYNTHESIS, CHARACTERIZATION AND THEIR BIOLOGICAL APPLICATIONS

Prof. Alka Pradhan, Anil Kumar Koshal* and Dharmendra Singh Khichi

Abstract

The chemistry of compounds possessing Schiff base moiety and Hydrazone moiety have been an interesting field of research since long time. 1-(4-aminophenyl) ethan-1-one was taken with thiosemicarbazide which gives 2-[1-(4-aminophenyl) ethylidene] hydrazine-1-carbothioamide. Hydrazone linkage containing 2-[1-(4- aminophenyl) ethylidene]hydrazine-1-carbothioamide derivatives are further condensed with’S aromatic aldehyde derivatives which gives a series of newly synthesized Schiff base. Synthesized derivatives of Schiff base are characterized by the physo chemical, physiological and IR. All synthesized compounds are screened for their antibacterial and antifungal activity by using agar well diffusion method. The results revealed that the compound IIA, IIB and IID show excellent activity against E. coli and moderate show against P. aerugenosaand and S.aureus. Compound IIB, IIE and IIF are show excellent against S.aureus. All compounds show moderate anti-fungal activity against A. flavus and A. fumigates and show excellent against Candida albicans.

Keywords: Hydrazone, Azomethine linkages and Biological applications.