Abstract

BROMOCRIPTINE MESYLATE- EFFERVESCENT FLOATING TABLETS

B. Raja Narender* and B. Mounika

Abstract

In the present research work was carried out to formulate Bromocriptine Mesylate- Effervescent Floating Tablets by using various polymers. Among all the formulations the formulations prepared by using Methocel K15 were unable to produce desired drug release; they were unable to retard drug release up to 12 hours. The formulations prepared with Methocel K4 M retarded the drug release up to 12 hours in the concentration of 7.5 mg (BR3). The formulations prepared with Gellan gum were also retarded the drug release for more than 12 hours. Hence they were not considere. The optimized formulation dissolution data was subjected to release kinetics, from the release kinetics data it was evident that the formulation followed peppas mechanism of drug release.

Keywords: Bromocriptine mesylate, Gellan gum, Methocel K4 M, Methocel K15 M and Floating tablets.