Abstract

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ISOLATED PH YTOSTEROL FROM LEAVES OF HOLOPTELEA INTEGRIFOLIA (RO XB.) PLANCH IN EXPERIMENTAL ANIMALS

Ravindra C. Sutar*

Abstract

Background: Majority of scientific documentation suggested promine nt role of Phytosterols towards Antidepressant activity. The main objective of the work was to evaluate Antidepressant activity of Holoptelea integrifolia isolated Phytosterol (HIIP) from petr oleum ether extract (PEHI) of leaves of Holoptelea integrifolia (Roxb) Planch. Methods: The Antidepressant activity of different doses of HIIP (10 a nd 30 mg/kg-p.o.) was evaluated using Tail Suspension Test (TST) in mice. Results: HIIP-30 mg/kg was more potent than HIIP-10 mg/kg for sho wing antidepressant activity. Conclusions: The results indicate that HIIP shows antidepressant activity which was dose dependent.

Keywords: Tail Suspension Test, Holoptelea integrifoila Isolated Phytosterol, Depression, Fluoxetine.