Abstract

ENHANCING ONSET OF ACTION OF CANDESARTAN CILEXETIL BY THE PREPARATION OF FAST DISSOLVING FILM CONTAINING LOADED CANDESARTAN CILEXETIL NANOEMULSION

*Sahil, Dr. Sarvesh Jain Malviya, Kalyani Khune and Dr. Puspendra Kumar Jain

Abstract

Candesartan cilexetil has limitation both in less bioavailability and onset of action. Therefor formulation to optimized the use of candesartan cilexetil. The purpose of this study was to develop nanoemulsion by using an appropriate oils, surfactant and co surfactant. Nanoemulsion was prepared by the spontaneous mixture of labrafil 2125, kolliphor RH 40 and PEG 400 with the ratio (0.5:9:5). The nanoemulsions were prepared by aqeous titration method. The solubility of drug was checked in different solvents, surfactant, oils and co surfactant in regulate to select the best solubilizing componenets for the preparation of nanoemulsion and then pseudoternary phase diagram was used as a useful device to evaluate the nanoemulsion area. The film was prepared by using a polymers (HPMC 5, HPMC 6, HPMC 15, and HPMC 50) and plasticizers. The method used for the preparation of film was petri plate method. It is an easy and low cost price method. The main purpose behind for the preparation of film was enhanced the onset of action and reduce the side effect. The evaluation of film was Invitro dissolution release, weight variation, folding endurance, film thickness, disintegration time, drug content release determination by used a zero order, first order, higuchi, koshmeyer plot graphs. The serious feature was type and ratio of oils, surfactant, co surfactant, and polymer and plasticizer concenteration influenced the film characters.

Keywords: Ternary plot, Polymer, Invitro drug release.