Abstract

TO OPTIMIZED THE DISSOLUTION AND SOLUBILITY PROPERTY OF CELECOXIB BY THE PREPARATION OF LIQUISOLID COMPACT

Ompal*, Dr. Sarveh Jain Malviya and Dr. Puspendra Kumar Jain

Abstract

“Liquisolid” technique is a novel and capable to development of dissolution rate and solubility of water-insoluble drugs like piroxicam, indomethacin, olmesartan, valsartan, and rosuvastatin. It is also used for the sustained and immediate release of the formulation. Liquisolid compact contains liquid medications in powder form. The liquisolid technique is the most competitive process for the formulation of waterinsoluble and water- soluble agents. The liquisolid compact is an admixture of the drug, nonvolatile solvent, coating material, carrier material. In this technique carrier and coating substance must be in a ratio of 3:1, 5:1, 7:1, 10:1, 15:1, 20:1, is mixed into the nonvolatile solvent. Dissolution Test of celecoxib was carried out by using a type 2 basket method (dissolution medium 900 ml, 7.4 pH of phosphate buffer, 100 r/m, 37±0.5ºC), to simulate the stomach or intestine solution. In this study, develop the solubility and dissolution properties of the celecoxib was investigated. Development of solubility and dissolution of the agents by use of non-volatile solvents (PEG 400, PEG200, and GLYCEROL), causes enhanced wettability and improves wettability leads to enhance solubility. Thereby it builds up the bioavailability. The liquisolid compact also contains carrier material and coating material (excipients). By using the liquisolid technique, solubility and dissolution rate is increased and immediate and sustained drug formulation can be developed for water-soluble drugs.

Keywords: Celecoxib, Liquisolid compact, Bioavailability, nonvolatile solvent, excipients.