Abstract

GREEN SYNTHESIS OF NANOSILVER AND ITS EFFECT ON PHASE SOLUBILITY OF FEW BCS CLASS II DRUGS

Dr. Ajit Shankarrao Kulkarni*, Mr. Kailas Madhukar Karande, Dr. Nagesh Hanumantrao Aloorkar, Mr. Jayprakash Sitaram Suryavanshi,

Abstract

Nanometals are developing tools for drug delivery systems owing totheir unique properties viz. surface plasmon resonance, high surface tovolume ratio, ability to interact not only with biomolecules but alsodrug molecules, precise therapeutic targeting etc. These core propertiespertaining to drug delivery make them potential tool in pharmaceuticalresearch.In present investigation, silver nanoparticles were synthesizedusing bioexcreta, cow urine and gelatin as stabilizing agent.Synthesized nanosilvers were characterized by absorptionspectroscopy, infrared spectroscopy, transmission electronspectroscopy and XRD. Absorption spectroscopy revealed successfulsynthesis of nanosilver. Fourier transform infrared spectroscopyshowed contribution of functional groups stabilizing nanosilver. TEM depicted sphericaluniform size and shape of nanosilver. XRD study revealed face centered cubic crystals. Thesenonfunctionalized nanosilvers were subsequently evaluated for acute toxicity study and foundsafe. Studies were also extended to confirm effect of synthesized NS on phase solubility ofsimvastatin and atorvastatin, and revealed appreciable increase in solubility of these drugs.Present investigations suggest that a green method can be used to synthesize NS which isecological, economical, and time efficient. Further, NS could enhance solubility ofsimvastatin and atorvastatin.

Keywords: Silver Nanoparticles, Green synthesis, Simvastatin, Atorvastatin.