Abstract

DESIGN AND DEVELOPMENT OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF MARAVIROC

Patel Rajendra*, Patel Dr. Arun, Patel Shailendra, Dwivedi Neelesh and Patel Bhavesh

Abstract

Self emulsifying drug delivery systems (SEDDS) are isotropic mixtures of natural or synthetic oils, solids or liquid surfactants or alternatively, one or more hydrophilic solvents, and co-solvents or cosurfactants Maraviroc SEDDS formulation when diluted with 250 times gives globule size of 110 nm and zeta potential of -5.18. There is no significant difference in globule size when diluted with medias like 0.1 N HCl and Phosphate buffer of pH 6.8). Maraviroc drug release from the SEDDS formulation was performed in 0.1 N HCl and 87.92 (± 4.78) % released within 15 minutes. In-vitro drug diffusion study in dialysis membrane showed that 80.56 ± 2.81% maraviroc diffused from the SEDDS formulation in the Phosphate buffer of pH 7.4 in five hours, whereas only 42.86 (±2.12) % released from Maraviroc suspension at the same conditions. Maraviroc SEDDS formulation can be used in the treatment of AIDS.

Keywords: AIDS, MARAVIROC, Self emulsifying drug delivery systems, HIV.