Abstract

FORMULATION AND EVALUATION OF FLOATING TABLETS OF DRUGS IN COMBINATION FOR SUSTAINED RELEASE ACTION

V. Koushal Kishore*, Dr. P. Arun, P. Shailendra, P. Bhavesh and D. Neelesh

Abstract

To developed and prepare a fine Gastroretentive dosage forms (GRDFs) with fine floating tablets of the combination of the two and investigate the possibility of those tablets as a delivery system for controlled release of ondansetron and immediate release of ranitidine. Gastroretention mode of administration would best achieve the known pharmacokinetic and pharmacodynamic advantages of CR-DFs of these drugs. The need for gastro retentive dosage forms (GRDFs) has led to extensive efforts in both academia and industry towards the development of such drug delivery systems. Ranitidine is given in combination with ondansetron A dissolution study shows the release of Ondansetron Hydrochloride and ranitidine hydrochloride. The Instant layer of ranitidine hydrochloride release Approx 99.45 percent drug within 15 minutes and control floating layer Ondansetron Hydrochloride shows release up to 12 Hours Approx 98.23 percent of Drug release in 12 hours. Experiment conclude that Bi-layer tablet is suitable for delivering same drugs with different release pattern like one layer of drug as immediate release to get quick relief and second drug as sustained release of drug which gives effect of drug for sufficient long time and reduce frequency of dose.

Keywords: HPMC K 30, PVP K30, Floating drug delivery system, Gastro retentive drug delivery system, Combination, Floating lag time.