Abstract

TRANSFERSOME FOR TREATMENT OF HERPES ZOOSTER OF ANTIVIRAL DRUGS

Amit Yadav*, Sailesh Narayan, Vishnu Raj and Reena Malviya

Abstract

Transfersome is a very versatile, push responsive and multifaceted total. Its favored shape is a ultra deformable vesicle having a watery center encompassed by the mind boggling lipid bi-layer. The name signifies "conveying body", and is duplicated from the Latin word 'transferre', signifying 'to convey over', and the Greek word 'soma', for a 'body. A Transfersome transporter is a manufactured vesicle and takes after the characteristic cell vesicle. In this way it is appropriate for focused and controlled medication delivery. Transfersomes are vesicles, which are self-improved totals with ultra-adaptable layer. These vesicular transfersomes are more flexible than the standard liposomes and in this manner appropriate for the skin penetration.[2] Transfersomes are advantageous as phospholipids vesicles for transdermal drug delivery. Because of their self-optimized and ultra flexible membrane properties, they are able to deliver the drug reproducibly either into or through the skin, depending on the choice of administration or application, with high efficiency. The vesicular transfersomes are more elastic than the standard Transfersomes and thus well suited for the skin penetration. Transfersomes overcome the skin penetration difficulty by squeezing themselves along the intracellular sealing lipid of the stratum corneum Skin permeation profile of acyclovir through transfersomes formulations was observed in the present study. The investigations revealed an enhanced transdermal delivery of acyclovir. Hence, it could be concluded that transfersomes may be suitable carrier for transdermal delivery of acyclovir.

Keywords: Transfersomes (Vesicular System), TDDS, Skin Penetration, Acyclovir, Gel permeability, Liposomes, FTIR, Entrapment.