Abstract

ANTIOXIDANT ACTIVITY OF ETHANOLIC EXTRACTS OF DAUCUS CAROTA LEAF

Jyoti Singh and R. K. Singh*

Abstract

The antioxidant properties in carrots were investigated in this study methanolic extract of daucus carota is used for antioxidant activity. oxidative stress were induced in rats by thioacetamide 100mg/kg s.c in four groups of rats(2 test, control, standard).The test groups received daucus carota leaf extract at doses of 200 and 400mg/kg. standard group received silymarin (25mg/kg) and control only thioacetamide on the animal were sacrified and brain like superoxide dismutase (SOD),Catalase (CAT), Glutathione reductase (GRD) and lipid Peroxidation were estimated in brain homogenate. The antioxidant enzyme a significant(P<0.001) increase in SOD,CAT,GRD was observed in all drug treated groups as compared with thioacetamide group. But in case of LPO a significant (P<0.001) reduction was observed as compared to toxic control group. DCLE has contributed to the reduction of oxidative stress of brain.

Keywords: Daucus carota leaf extract, Silymarin, Lipid Peroxidation, ROS.