Abstract

NANOTECHNOLOGICAL ADVANCES TOWARDS ALZHEIMER’S DISEASE TREATMENT

Anurag Sangwan, Parth Malik*

Abstract

Ever since the development of medical science, effective diagnosis and treatment of neurological disorders have been a prominent question of interestfor medical specialists and research community all over the world. Alzheimer‘s disease (AD) is one of these troublesome disorders with complex pathophysiological background. Current treatment available enables a weak detection and prolongs only the appearance of related symptoms. This has considerably effected the severity of this disorder and consequently it has been presumed within the scientific brains across the world that death is the only destiny for sufferers. However, a ray of hope has been discovered in the better diagnosis and handling of this disease at the clinical stage by nanotechnologists which not only enables the early detection, but also significantly improves the treatment methodologies involved. This requires the crossing of complex blood brain barriers. Nanocarriers such as nanoemulsion, nanosuspensions and dendrimer encapsulated with suitable drug formulations can be engineered to ensure targeted and sustained release at effected sites within the brain, so as to treat the disease in a better way. This article reviews various nanotechnological insights with an aim to cure the pathogenic impacts of AD along with a thorough understanding of molecular aspects associated with the occurrence of AD.

Keywords: Alzheimer‘s disease (AD), neurodegenerative disease, nanotechnology, nanoemulsions, dendrimers.